Along with panels, seminars, and workshops with comic book professionals, there are previews of upcoming feature films, portfolio review sessions with top comic book and video game companies, and such evening events as awards ceremonies and The Masquerade; a costume contest, and the Comic-Con International Independent Film Festival which showcases shorts and feature length movies that do not have distribution or distribution deals.

Like most comic book conventions, Comic-Con features a large floorspace for exhibitors. These include media companies such as movie studios and TV networks, as well as comic-book dealers and collectibles merchants. Like most comics conventions, Comic-Con includes an autograph area, as well as an "artists' alley" where comics artists can sign autographs and sell or do free sketches. Despite the name, artists' alleys can include writers and even models.